Targeted Liposomes: A Nonviral Gene Delivery System for Cancer Therapy
WEBApr 8, 2022 · The aptamer AS1411 was used to functionalize cationic liposome coloaded with polo-like kinase 1 siRNA and paclitaxel for breast cancer therapy. Gene therapy using siRNA targeting polo-like kinase 1 is a promising strategy, given that the overexpression of this protein in cancer cells is related to cell proliferation, metastasis, and angiogenesis.
Liposomal delivery of gene therapy for ovarian cancer: a …
WEBAug 23, 2023 · Liposomal delivery of gene therapy for ovarian cancer shows promise in many in vivo studies. Emerging polymer-coated and ligand-targeted liposomes have been gaining interest as they have been shown to have more stability and specificity.
A Review of Liposomes as a Drug Delivery System: Current Status …
WEBFeb 17, 2022 · Liposomes have been considered promising and versatile drug vesicles. Compared with traditional drug delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from degradation and clearance, superior therapeutic effects, and lower toxic side effects.
Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a ...
WEBJun 28, 2021 · Immunoliposomes, sterically stabilized liposomes, and cationic liposomes are the most commonly used LNPs for antitumor therapy. Understandably, cationic liposomes are the preferred formulation for gene therapy, and immunoliposomes are preferred as delivery vehicles for immunotherapies, including cancer immunotherapy.
Engineering liposomal nanoparticles for targeted gene therapy
WEBMay 15, 2017 · Immunoliposomes, targeted via antibody–receptor interactions, have widely expanded the therapeutic potential of targeted liposomal gene therapy, with new ligands, such as T-cell receptor-like ...
Liposomes in the Targeted Gene Therapy of Cancer: A Critical
WEBControlling the physical architecture and chemical properties of liposome structures, such as lipid-to-DNA charge, ester bond composition, size, and ligand complexation structure, is critical for targeting liposomes' success as vehicles for gene delivery.
Liposomal delivery of CRISPR/Cas9 | Cancer Gene Therapy - Nature
WEBNov 2, 2019 · Liposomes are one of the most widely investigated carriers for CRISPR/Cas9 delivery. The surface properties of liposomal carriers, including the surface charge, PEGylation, and ligand...
Controlled gene and drug release from a liposomal delivery ... - Nature
WEBJul 13, 2018 · Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors. Article Open access 21 February 2022. Liposomal nanotheranostics for multimode targeted in...
Engineering liposomal nanoparticles for targeted gene therapy
WEBHere, we discuss the latest breakthroughs in the development of targeted liposome-based agents for the delivery of genetic material, paying particular attention to new ligand and cationic lipid design as well as recent in vivo advances.
Targeted Liposomes: A Nonviral Gene Delivery System for Cancer Therapy
WEBApr 8, 2022 · Thus, gene therapy has been a potential therapeutic approach owing to its ability to introduce, silence, or change the content of the human genetic code for inhibiting tumor progression, angiogenesis, and metastasis.