Rice was quickly ruled questionable to return after receiving additional attention in the locker room, then downgraded to out at the end of the first quarter. Coach Andy Reid told CBS' Tracy Wolfson later in the game that he doesn't know the severity of the injury, but added that it's "not good."

Rice was carted off the field in the first quarter and did not return to the game after being evaluated. The wide receiver was involved in a collision with Patrick Mahomes and a few Chargers players after the Chiefs quarterback threw an interception. Following the win for the Chiefs, head coach Andy Reid sent said he feels "terrible" for Rice.

Rice did not make a catch prior to exiting Sunday's game. He had been far and away Patrick Mahomes's most targeted receiver during the first three games of the season, during which he racked up 24 receptions on 29 targets for 288 yards and two touchdowns.