Bills vs. Jaguars odds, prediction, time: NFL picks, Monday Night Football bets by model on 41-22-run
Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 7:30 p.m. ET. The Bills are 5.5-point favorites in the latest Jaguars vs. Bills odds, while the over/under for total points scored is 45.5. Before making any Bills vs. Jaguars picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.
The Buffalo Bills host the Jacksonville Jaguars in one of two Monday Night Football games on Monday, Sept. 23.
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